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. Author manuscript; available in PMC: 2016 Aug 19.
Published in final edited form as: Sci Signal. 2016 Feb 2;9(413):ra12. doi: 10.1126/scisignal.aad3210

Fig. 6.

Fig. 6

ABL kinases regulate the expression of genes in the JAK/STAT and Hippo pathway signatures in metastatic breast cancer cells.

(A) CummeRbund Heatmap of genes that were differentially expressed in control and single and double ABL1 and ABL2 knockdown cells. (B) GSEA analysis of the indicated gene signatures in ABL1/ABL2 knockdown cells (shAA) compared with control cells (Scr). NES, Normalized Enrichment Score (C) Expression of the indicated genes in control, ABL1 or ABL2 single knockdown and ABL1/ABL2 double knockdown cells quantified using Cufflinks CuffDiff. * indicates significantly (p<0.05 after Benjamini-Hochberg Correction for multiple-testing) different from Scr. Error bars represent Standard Deviation (SD). N=3 biological replicates for (A) and (C).