ABL kinases activate TAZ and STAT5 pathways to promote breast cancer bone metastasis.
(A) Kaplan-Meier representation of the probability of cumulative overall disease free survival in TCGA dataset with 971 invasive breast cancer patients according to whether the ABL signature (ABL2, TAZ, AXL, CTGF, STAT5A, STAT5B, TNC, IL6, MMP1) was altered or not. P value was derived by log rank test.
(B) Model for the role of ABL kinases in the regulation of breast cancer bone metastasis.