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. Author manuscript; available in PMC: 2016 Aug 19.
Published in final edited form as: Int J Nano Stud Technol. 2016 Jul 27;Suppl 4:1–18. doi: 10.19070/2167-8685-SI04001

Figure 3.

Figure 3

A photoactivable multi-inhibitor liposome (PMIL) for targeting multiple hallmarks of cancer. (A) Synthesis of a PMIL loaded with a benzoporphyrin derivative (BPD) in the lipid bilayer and cabozantinib (XL184) loaded in the liposomal core. (B) Treatment mechanism of PMILs, illustrating the multiple targeted hallmarks. (C) Fraction of residual tumor in a mice model 19 days after treatment. PMILs had greater tumor reduction compared to free XL184, XL184 loaded in a liposomal construct, BPD loaded in a liposomal construct, and a combination of liposomes with BPD and liposomes with XL184. (D) Comparison of the different methods mentioned in (C) in the number of cancer cells that exhibited liver and lymph node metastasis after treatment. PMILs had the least number of cancer cells exhibiting metastasis after treatment [32]. Reproduced from [32] by permission of Nature Publishing Group (NPG).