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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Genes Brain Behav. 2016 Apr;15(4):382–394. doi: 10.1111/gbb.12288

Figure 10.

Figure 10

Increased Toll activity produces ethanol resistance in a Dif-dependent manner. 0 minutes denotes the beginning of the recovery period. A) A Dif1 mutation blocks the effect of overexpressing constitutively active UAS-Toll10B using Actin-GeneSwitch (p=0.38). Overexpressing Toll10B with functional Dif increases resistance (see Fig. 3E). B) Dif is haploinsufficient with respect to ethanol resistance: Dif1 heterozygotes are less resistant to ethanol sedation (p<0.0001). The animals in Fig. 10A are heterozygous for Dif1, whereas the Dif1 mutants reported in Fig. 7A were homozygous.