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. 2016 Jul 14;7(3):292–300. doi: 10.1080/19491034.2016.1187353

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Two levels of budding yeast origin flexibility. Mcm2-7 complexes are preferentially loaded at canonical origin sites that contain a high-affinity ORC binding site (top). Mutation of the high-affinity ORC binding site at a canonical origin can redirect ORC to lower-affinity binding sites in the template, resulting in Mcm2-7 loading at non-canonical origin sites (bottom left). Collisions between Mcm2-7 DHs and other DNA translocases at replication origins can induce the sliding of Mcm2-7 to non-canonical origin sites (bottom right)/ ARS: Autonomously replicating sequence.