Table 2.
Stapled Noxa peptides described by Lin and co‐workers.[28]
| Compound | Sequence[a] | K i [nm][b] | Cell Viability [%][b] |
|---|---|---|---|
| Noxa | AAQLRRIGDKVNLRQKLLN | 648±128 | 97.6±0.9 |
| Noxa 1 | AAC′LRRIGDC′VNLRQKLLN | 10±1 | 98.6±4.0 |
| Noxa 2 | AAc′LRRIGDC′VNLRQKLLN | 54±14 | 100.3±0.2 |
| Noxa 3 | AAc′LRAIGDC′VNLRQKLLN | 23±8 | 85.9±2.2 |
| Noxa 4 | AAc′LRAIGDC′VNLAQKLLN | 28±11 | 72.9±3.2 |
| Noxa 5 | AAc′LRAIGDC′VNLAQALLN | 29±4 | 44.3±0.2 |
| Noxa 6 | AmAc′LRRIGDC′VNLRQKLLN | 32±3 | 87.3±2.8 |
| Noxa 7 | AmAmc′LRRIGDC′VNLRQKLLN | 22±4 | 80.5±4.7 |
| Noxa 8 | AmAmc′LRAIGDC′VNLAQALLN | 22±8 | 34.8±0.5 |
[a] C′=Bph‐linked l‐Cys, c′=Bph‐linked d‐Cys, Am=N‐methylalanine. [b] Data are the mean±SD, n=3.