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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Behav Brain Res. 2016 Jul 18;313:244–254. doi: 10.1016/j.bbr.2016.07.024

Fig. 3.

Fig. 3

Effect of nicotine and social stimuli on CPP expression. Nicotine (0.1 mg/kg S.C.) and/or social reward-CPP shown as time (means + SEM) spent in the partner and/or nicotine-paired side pre-conditioning (i.e., Baseline, white bars) vs. postconditioning (i.e., Test, black bars) across groups. The dotted line represents 50% of the total test time (i.e., 300 s). (A) In Experiment 1 (n = 9–11/group), conditioning took place across two consecutive days. Nicotine-conditioned groups exhibited greater CPP compared to saline-conditioned groups (p < 0.05, ANOVA). (B) In Experiment 2 (n = 10/group), conditioning took place across 4 consecutive days with CS+ sessions occurring on the 1st and 4th day and CS− sessions occurring on the 2nd and 3rd day. Only the Nic + Soc group exhibited significant CPP compared to the Sal + Iso group. Asterisk (*) represents an increase compared to Sal + Iso test (ps < 0.0167, Bonferroni).