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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Behav Brain Res. 2016 Jul 18;313:244–254. doi: 10.1016/j.bbr.2016.07.024

Fig. 4.

Fig. 4

Effect of nicotine and social stimuli alone on IEG expression. Number of Fos- and Zif268-positive nuclei + SEM in regions exhibiting group differences among rats sacrificed 90-min after the last US conditioning session in the CS+ side of the apparatus. US conditions included either saline (Sal) or nicotine (Nic) injections followed by placement into the initially nonpreferred side of the CPP apparatus either alone (Iso) or with a social partner (Soc) in Experiment 2 (n = 7–10/group). Means of Fos- (A) and Zif268-positive (B) cells shown are collapsed across Drug condition. Asterisk (*) represents a main effect of Social Condition, where social pairings increased expression relative to isolation (ps < 0.05, ANOVA). Means of Fos- (C) and Zif268-positive (D) cells shown are collapsed across Social Condition. Plus sign (+) represents a main effect of Drug, where nicotine decreased expression relative to saline (ps < 0.05, ANOVA).