Table 1.
Mean (±SEM) of Fos-positive nuclei for each region for Experiments 1 and 2.
| Brain Regionb | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experiment 1 Groupa | Cg1 | Cg2 | dmCPu | dlCPu | NAcC | NAcSh | MeA | CeA | BLA | VTA |
| Sal + Iso | 95 ± 10.1 | 115 ± 13.9 | 17 ± 4.3 | 3 ± 0.8 | 73 ± 7.6 | 38 ± 3.7 | 62 ± 4.8 | 33 ± 3.7 | 67 ± 5.7 | 7 ± 1.6 |
| Sal + Soc | 92 ± 6.3 | 91 ± 8.8 | 16 ± 2.4 | 4 ± 1.1 | 67 ± 3.9* | 33 ± 2.6 | 56 ± 3.7 | 33 ± 2.8 | 52 ± 2.2 | 8 ± 1.2 |
| Nic + Iso | 106 ± 13.2 | 99 ± 8.9 | 21 ± 4.2 | 5 ± 1.1 | 72 ± 9.1 | 32 ± 4.1 | 59 ± 3.0 | 37 ± 3.6 | 64 ± 5.4 | 7 ± 2.5 |
| Nic + Soc | 119 ± 8.0 | 99 ± 7.5 | 17 ± 2.9 | 4 ± 0.7 | 52 ± 3.7* | 36 ± 2.9 | 64 ± 4.0 | 34 ± 3.2 | 64 ± 4.7 | 8 ± 1.0 |
| Experiment 2 Groupa | Cg1 | Cg2 | dmCPu | dlCPu | NAcC | NAcSh | MeA | CeA | BLA | VTA |
|---|---|---|---|---|---|---|---|---|---|---|
| Sal + Iso | 92 ± 10.5 | 87 ± 16.0 | 19 ± 4.0 | 3 ± 0.6 | 36 ± 4.6 | 25 ± 3.1 | 13 ± 1.8 | 10 ± 2.0 | 28 ± 4.0 | 6 ± 0.6 |
| Sal + Soc | 102 ± 7.4 | 98 ± 13.1 | 26 ± 4.7 | 10 ± 1.7* | 52 ± 6.1* | 37 ± 2.5* | 13 ± 1.8* | 14 ± 2.3* | 20 ± 2.3 | 4 ± 0.5#† |
| Nic + Iso | 55 ± 8.2+ | 54 ± 8.0+ | 12 ± 2.8 | 1 ± 0.3+ | 23 ± 5.2+ | 20 ± 3.1 | 9 ± 1.0 | 11 ± 2.0 | 15 ± 1.9#† | 4 ± 0.8# |
| Nic + Soc | 77 ± 6.3+ | 62 ± 5.3+ | 17 ± 3.9 | 5 ± 1.6*+ | 38 ± 6.2*+ | 34 ± 2.5* | 17 ± 2.5* | 17 ± 2.7* | 24 ± 2.5 | 6 ± 0.8 |
Asterisk (*) indicates a main effect of Social Condition, p < 0.05; plus sign (+) indicates a main effect of Drug, p < 0.05; pound sign (#) indicates a decrease relative to Sal + Iso negative control group (ps ≤ 0.05, post-hoc independent samples t-test following a Drug × Social Condition interaction); dagger (†) represents a decrease relative to Nic + Soc (ps < 0.05, post-hoc independent samples t-test following a Drug × Social interaction).
a
Saline (Sal), Nicotine (Nic), Isolation (Iso), and Social partner (Soc).
b
Abbreviations are described in the Methods (Immunoreactivity analysis) section and Fig. 2.