Table 2.

Mean (±SEM) of Zif268-positive nuclei for each region for Experiments 2.

Brain Regionb
Experiment 2 Groupa	Cg1	Cg2	dlCPu	NAcC	NAcSh	MeA	CeA	BLA	VTA
Sal + Iso	252 ± 14	324 ± 21	466 ± 20	246 ± 28	166 ± 35	199 ± 19	188 ± 23	177 ± 28	4.2 ± 0.8
Sal + Soc	261 ± 15	333 ± 22	511 ± 31*	254 ± 13*	175 ± 21	228 ± 21*	247 ± 39	264 ± 23*	2.6 ± 0.5
Nic + Iso	220 ± 13+	296 ± 11+	341 ± 28+#†	185 ± 23	147 ± 27	185 ± 17	214 ± 24	180 ± 23	2.2 ± 0.4#
Nic + Soc	247 ± 10+	306 ± 13+	495 ± 21*+	263 ± 15*	161 ± 17	245 ± 19*	256 ± 14	213 ± 21*	3.3 ± 0.5

Asterisk (*) indicates a main effect of Social Condition, p < 0.05; plus sign (+) indicates a main effect of Drug, p < 0.05; pound sign (#) indicates a decrease relative to Sal + Iso negative control group (ps ≤ 0.05, post-hoc independent samples t-test following a Drug × Social Condition interaction); dagger (†) indicates a decrease relative to Nic + Soc (ps < 0.05, post-hoc independent samples t-test following a Drug × Social interaction).

^aSaline (Sal), Nicotine (Nic), Isolation (Iso), and Social partner (Soc).

^bAbbreviations are described in the Methods (Immunoreactivity analysis) section and Fig. 2.