Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding affinity of subclass-switch family mAbs and 3C5 IgG3 F(ab')2 fragments given as a function of RUs generated by concentration. Data are shown from a representative experiment. The steady-state model from BIAevaluation software was applied to each graph in Fig. 2 to determine the dissociation constant (KD) of each mAb. A smaller KD corresponds to a higher affinity. Note the higher mAb concentrations needed for calculation of affinity for the 3C5 non-IgG3 mAbs.
