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. 2016 Mar 24;7(15):19185–19192. doi: 10.18632/oncotarget.8313

Figure 1. Workflow.

Figure 1

We first searched PubMed with FOXOs keywords and found more than 2700 papers. Through manually reading these papers, we got 208 FOXOs direct targets. Inparanoid was used to map FOXOs targets to their orthologs in C. elegans. And 109 genes were found eventually. Bioinformatics analysis on the 109 genes were done including comparison with previous results, transcription factor binding site enrichment, lifespan regulation and network topological feature analysis. And we built a database to make all data easily accessible.