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. 2016 Feb 3;7(15):19468–19482. doi: 10.18632/oncotarget.7153

Figure 5. Pubertal BA exposure impacts testis physiology via FXRα.

Figure 5

A. Relative intra-testicular bile acid levels in C57Bl6.mice fed control or CA diet for 5 days (n=5-6 per group). B. Relative intra-testicular testosterone levels in C57Bl6.mice treated with vehicle or GW4064 for 5 days (n=5-6 per group). C. Testicular mRNA expression of Star normalized to β-actin levels in whole testis of C57Bl/6J mice treated with vehicle or GW4064 for 5 days (n=10 to 15 per group). D. Quantification of TUNEL analyses in males treated with vehicle or GW4064 for 5 days. The number of TUNEL-positive spermatocytes is indicated as the number of positive cells per 100 seminiferous tubules (n=10-20). E. Relative intra-testicular testosterone levels in Fxrα−/− male mice treated with vehicle or GW4064 for 5 days (n=5-6 per group). F. Testicular mRNA expression of Star normalized to β-actin levels in whole testis of Fxrα−/− male mice mice treated with vehicle or GW4064 for 5 days (n=10 to 15 per group). G. Quantification of TUNEL analyses in Fxrα−/− male mice treated with vehicle or GW4064 for 5 days. The number of TUNEL-positive spermatocytes is indicated as the number of positive cells per 100 seminiferous tubules (n=10-20). In all panels control diet or vehicle treated group were arbitrarily fixed at 100% and data are expressed as the means ± SEM. Statistical analysis: *, p<0.05; **, p<0.01, ***, p<0.005 vs.respective control group.