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. 2016 Feb 3;7(15):19468–19482. doi: 10.18632/oncotarget.7153

Figure 6. BA act in though FXRα in a SHP independent manner in pubertal males.

Figure 6

A. Testicular mRNA expression of Shp, Lrh-1and Sf-1 normalized to β-actin levels in whole testis of C57Bl/6J mice fed control or CA diets for 5 days (n=5 to 10 per group). B. Percentage of infertile males in Shp+/+ and Shp−/− exposed to CA diet for 44 days. C. Total number of pups obtained per group in Shp+/+ and Shp−/− exposed to control or CA diet for 44 days. D. Relative intra-testicular testosterone levels in Shp−/− mice fed control or CA diet for 5 days (n=6-10 per group) E. Quantification of TUNEL analyses in Shp−/− males fed control or CA diets for 5 days. The number of TUNEL-positive spermatocytes is indicated as the number of positive cells per 100 seminiferous tubules (n=6-10). In all of the panels data are expressed as the means ± SEM. Statistical analysis:*, p<0.05; **, p<0.01, ***, p<0.005 vs.respective control group.