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. 2016 Feb 3;7(15):19468–19482. doi: 10.18632/oncotarget.7153

Figure 9. BA signaling pathway alters LH/CG sensitivity at the Leydig cell level in pubertal males.

Figure 9

A. Relative progesterone levels in medium of MA10 cells pre-treated 12h with vehicle or GW4064 and then 4 hours with veh or hCG (n=5-15 per group). B. mRNA expression of Star normalized to β-actin levels in MA10 cells pre-treated 12h with vehicle or GW4064 and then 4 hours with veh or hCG (n=5-15 per group). C. Representative western bots of P-CREB and CREB, and quantification of the P-CREB/CREB ratio in MA10 cells MA10 cells pre-treated 12h with vehicle or GW4064 and then 30min with veh or hCG (n=5-15 per group). D. mRNA expression of Star normalized to β-actin levels in MA10 cells pre-treated 12h with vehicle or GW4064 and then 4 hours with veh or Fsk (n=5-15 per group). E. mRNA expression of Star normalized to β-actin levels in MA10 cells pre-treated 12h with vehicle or GW4064 and then 4 hours with veh or 8Bromo-AMPc (n=5-15 per group). F. Relative progesterone levels in medium of MA10 cells pre-treated 6h with vehicle or GW4064 and then 4 hours with veh or hCG (n=5-10 per group). In all panels data are expressed as the means ± SEM. Statistical analysis:*, p<0.05; **, p<0.01, ***, p<0.005 vs.respective control group.