Figure 3. TGF-β1, TGF-β2 and Collagen 1a1 expression in acute and chronic CCl₄- induced liver damage.

(A) Within six days, expression dynamics of TGF-β1 and −β2 and Collagen 1a1 in the CCl₄ regeneration model (1 hit) were determined by qPCR in comparison to untreated controls (B) TGF-β1 and −β2 mRNA expression was assessed 24 h after 1 CCl₄ injection, 3 injections within one week or two injections per week for six weeks as indicated. (C) TGF-β1 and −β2 expression were correlated with Col 1a1 expression in 7 individual mice with chronic liver damage (6 weeks treatment). Pearson coefficients were r_{TGF-β1/TGF-β2} = 0.891, r_{TGF-β1/Col1A} = 0.723, r_{TGF-β2/Col1A} = 0.701, respectively.