Table 1. HCC sample cohorts used for Oncomine® Research Edition based analysis of TGF-β1 and TGF-β2 expression.
| TGF-β2 | Publication | Samples | Measured Genes Total | Overexpression | Underexpression | ||||
|---|---|---|---|---|---|---|---|---|---|
| TGF-β2 Gene Rank | Fold Change (Median Centered Ratio) | p-Value | TGF-β2 Gene Rank | Fold Change (Median Centered Ratio) | p-Value | ||||
| 1 | Chen Liver. Mol Biol Cell. 2002 [76] | 197 | 10.802 | 5239 (in top 49%) | 1.107 | 0.221 | 2569 (in top 24%) | −1.258 | 0.006 |
| 2 | Guichard Liver. Nat Genet. 2012 [77] | 185 | 18.823 | 838 (in top 5%) | 1.114 | 1.08E–14 | 17148 (in top 92%) | 1.114 | 1.000 |
| 3 | Guichard Liver 2. Nat Genet. 2012 [77] | 52 | 18.823 | 787 (in top 5%) | 1.103 | 4.32E–6 | 17195 (in top 92%) | 1.103 | 1.000 |
| 4 | Mas Liver. Mol Med. 2008 [78] | 115 | 12.603 | 890 (in top 8%) | 1.191 | 1.56E–6 | 3547 (in top 29%) | −1.076 | 0.003 |
| 5 | Roessler Liver. Cancer Res. 2010 [79] | 43 | 12.603 | 4250 (in top 34%) | 1.194 | 0.046 | 5540 (in top 44%) | −1.029 | 0.118 |
| 6 | Roessler Liver 2. Cancer Res. 2010 [79] | 445 | 12.624 | 5015 (in top 40%) | 1.053 | 0.001 | 5115 (in top 41%) | −1.034 | 0.004 |
| 7 | TCGA Liver. No Associated Paper. 2012 | 212 | 18.823 | 792 (in top 5%) | 1.233 | 3.40E–15 | ND | ND | ND |
| TGF-β1 | Publication | Samples | Measured Genes Total | TGF-β1 Gene Rank | Fold Change (Median Centered Ratio) | p-Value | TGF-β1 Gene Rank | Fold Change (Median Centered Ratio) | p-Value |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Chen Liver. Mol Biol Cell. 2002 [76] | 197 | 10.802 | 10452 (in top 97%) | −1.557 | 1.000 | 512 (in top 5%) | −1.557 | 1.56E–12 |
| 2 | Guichard Liver. Nat Genet. 2012 [77] | 185 | 18.823 | 5712 (in top 31%) | 1.013 | 0.060 | 12282 (in top 66%) | 1.013 | 0.940 |
| 3 | Guichard Liver 2. Nat Genet. 2012 [77] | 52 | 18.823 | ND | ND | ND | 11608 (in top 62%) | 1.007 | 0.820 |
| 4 | Mas Liver. Mol Med. 2008 [78] | 115 | 12.603 | 1784 (in top 15%) | 1.513 | 1.40E–4 | X | X | X |
| 5 | Roessler Liver. Cancer Res. 2010 [79] | 43 | 12.603 | 1836 (in top 15%) | 2.225 | 3.09E–4 | 5267 (in top 42%) | −1.071 | 0.093 |
| 6 | Roessler Liver 2. Cancer Res. 2010 [79] | 445 | 12.624 | 5677 (in top 45%) | 1.098 | 0.043 | 3088 (in top 25%) | −1.111 | 3.69E–7 |
| 7 | TCGA Liver. No Associated Paper. 2012 | 212 | 18.823 | 5854 (in top 32%) | 1.027 | 0.021 | 12130 (in top 65%) | 1.027 | 0.979 |
Total number of samples, number of genes measured, p-values, gene ranks, and the fold change are given for TGF-β1 and TGF-β2 as indicated. Additionally, the table summarizes in which range of differentially expressed genes the respective gene was found in the study (top %). ND = not detected in the study.