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. 2016 Jan 21;7(15):19548–19558. doi: 10.18632/oncotarget.6969

Figure 4. Embelin decreased vascularity and MMP2 expression in late carcinoma stage.

Figure 4

(A) Vascular density in colonic tumors from mice treated with or without embelin at day 85 was evaluated by immunostaining with anti-CD31 antibody. Scale bar: 50 μm. Data were quantified by blind counting of blood vessels per microscopic field (B). Relative mRNA expression of MMP2 in colonic tumor was analyzed by qPCR (C), and representative immunostaining of MMP2 in colonic tumor at day 85 after AOM/DSS exposure was shown (D). Scale bar: 50 μm. E. The number of MMP2+ cells per field was quantified (n > 10 fields/group). Data are expressed as mean ± SD (n = 6–8/group; *p < 0.05).