Skip to main content
. 2016 Feb 25;7(15):19723–19737. doi: 10.18632/oncotarget.7736

Figure 2. miR-137 and miR-6500-3p suppress cell proliferation and have a combined effect with TMZ treatment.

Figure 2

RT-qPCR confirmed downregulation of miR-137 and miR-6500-3p expression in pHGGs (n = 12) compared to pLGGs (n = 12) A. Overexpression of miR-137 B. or miR-6500-3p C. decreases cell proliferation in SF188 cells, and miR-137 knockdown D. increases cell proliferation in Res259 cells as measured by MTT assay. The effects of overexpression were evaluated by RT-qPCR. The effects of miR-137 or miR-6500-3p overexpression on SF188 cells (left panel) and of miR-137 knockdown on Res259 cells (right panel) were evaluated by flow cytometry E. SF188 cells overexpressing miR-137 F. or miR-6500-3p G. were treated with either DMSO or TMZ and cell proliferation was measured at different time points by MTT assay. Results are presented as mean±SD for duplicate samples. *p < 0.05, **p < 0.01 by t-test.