Table 3. Sensitivity (%Sn), specificity (%Sp), and area under curve (AUC) for univariate QUS and DOSI parameters.
| Week 1 | Week 4 | Week 8 | Pre-Op | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameters | %Sn | %Sp | AUC (Logistic) | %Sn | %Sp | AUC (Logistic) | %Sn | %Sp | AUC (Logistic) | %Sn | %Sp | AUC (Logistic) |
| MBF | 50.0 | 50.0 | 0.607 | 92.9 | 100 | 0.982 | 100 | 100 | 1.000 | 71.4 | 75.0 | 0.804 |
| SI | 64.3 | 87.5 | 0.839 | 85.7 | 87.5 | 0.920 | 92.9 | 87.5 | 0.991 | 64.3 | 62.5 | 0.634 |
| SS | 28.6 | 25.0 | 0.201 | 57.1 | 62.5 | 0.643 | 28.6 | 25.0 | 0.295 | 64.3 | 62.5 | 0.616 |
| Hb | 64.3 | 62.5 | 0.616 | 85.7 | 87.5 | 0.911 | 100 | 100 | 1.000 | 92.9 | 100 | 0.982 |
| HbO2 | 85.7 | 87.5 | 0.982 | 85.7 | 87.5 | 0.938 | 100 | 100 | 1.000 | 100 | 100 | 1.000 |
| HbT | 78.6 | 75.0 | 0.875 | 85.7 | 87.5 | 0.964 | 100 | 100 | 1.000 | 100 | 100 | 1.000 |
| %Water | 50.0 | 50.0 | 0.589 | 85.7 | 75.0 | 0.848 | 71.4 | 75.0 | 0.732 | 85.7 | 87.5 | 0.902 |
| %Lipids | 50.0 | 50.0 | 0.527 | 92.9 | 87.5 | 0.982 | 100 | 100 | 1.000 | 100 | 100 | 1.000 |
| SP | 50.0 | 50.0 | 0.527 | 92.9 | 87.5 | 0.982 | 100 | 100 | 1.000 | 100 | 100 | 1.000 |
| SA | 57.1 | 50.0 | 0.393 | 85.7 | 87.5 | 0.897 | 92.9 | 75.0 | 0.884 | 85.7 | 87.5 | 0.870 |
| TOI | 64.3 | 62.5 | 0.625 | 85.7 | 87.5 | 0.973 | 100 | 100 | 1.000 | 100 | 100 | 1.000 |
QUS and DOSI parameters were analyzed for weeks 1, 4 and 8 to correspond to response monitoring during treatment. Markers for response classification were detected as early as one week relative to the start of chemotherapy.