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. 2016 Mar 2;7(15):19794–19812. doi: 10.18632/oncotarget.7847

Figure 7. DDA1 promotes colon cancer progression by stimulating NFκB/CSN2/GSK3β signaling.

Figure 7

(A) Immunofluorescence analyses showed increased p65 nuclear translocation in HT-29/LV-DDA1 cells as compared with HT-29/LV-vector, but decreased in SW480/shDDA1 compared with SW480/Scramble. (B) Expression of DDA1/NFκB/CSN2/GSK3β pathway proteins in HT-29/LV-DDA1, DLD-1/LV-DDA1, SW480/shDDA1#1 and SW620/shDDA1#1 cells. (C and D) Changes in DDA1/NFκB/CSN2/GSK3β signaling proteins in HT-29/LV-DDA1 and DLD-1/LV-DDA1 cells after treatment with BAY-11-7082 and Helenalin. (E) Changes in DDA1/NFκB/CSN2/GSK3β pathway proteins in HT-29/LV-DDA1 and DLD-1/LV-DDA1 cells after transfection with IKKβ siRNA and Scramble.