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. 2016 Mar 2;7(15):19813–19823. doi: 10.18632/oncotarget.7852

Figure 1. Somatic mutations detected in whole exome sequencing sample and deep sequencing samples.

Figure 1

(A) Resequencing of RASSF6 mutation in one of the whole exome sequencing samples. A heterozygous frameshift mutation (c.367insA (T), p.R123fs*20) in exon 5. (B) A heterozygous missense mutation (c.746A > T, p.D249V) in exon 9 identified in one of the deep sequencing samples. (C) A heterozygous missense mutation (c.992T > A, p.I331K) in exon 11. (D) Overview of 3 somatic mutations in protein level. RASSF6 contains two domains: RA domain and SARAH domain. △ represents frameshift mutation while ☆ represents missense mutation.