Table 4. p-values and nature of the relationship between the sinusoids and the INRG poor-prognostic factors.
| Parameter | Stage: metastatic | Age: >18 months | Histopathology: (pd, uNB) | MYCN: MNA | Genetic profile: SCA | 11q: 11qD | Risk group: high-risk |
|---|---|---|---|---|---|---|---|
| Density | 0.050↑ | - | 0.041↑ | - | - | - | - |
| SA | - | - | 0.024↑ | - | - | - | - |
| Rel. density | 0.043↑ | - | - | 0.004↑ | - | - | 0.034↑ |
| Rel. SA | - | - | - | - | - | - | - |
| Area | - | - | 0.035↑, *0.009↑ | 0.000↑ | - | - | 0.001↑ |
| Length | - | - | - | 0.015↑ | - | - | - |
| Width | 0.024↑ | - | 0.018 ↑ | 0.004↑ | - | - | 0.001↑ |
| Perimeter | - | - | - | - | - | - | - |
| Aspect | 0.001↓ | - | 0.005↓ | 0.017↓ | - | - | 0.001↓ |
| Roundness | 0.018↓ | - | *0.011↓ | 0.000↓ | - | - | 0.000↓ |
| Per. ratio | - | - | 0.016↓ | 0.022↑ | - | - | - |
| Deformity | - | - | - | - | - | - | - |
| Shape factor | 0.000↓ | - | 0.001↓, *0.043↓ | 0.000↓ | - | - | 0.000↓ |
| Branching | 0.017↑ | 0.033↑ | - | 0.043↑ | - | - | 0.000↑ |
SA: Stained area Rel. density: relative density, Rel. SA: relative SA, Per. ratio: perimeter ratio, -: not statistically significant, ↑/↓: higher or lower median value for the poor-prognostic group(s)
*
statistically significant differences between the different degrees of differentiation within the NB histological category.