Table 6. Influence of INRG prognostic factors and morphometric variables of total vascularization and blood vessel segments with value as new prognostic factors on poor EFS and/or OS of neuroblastoma patients.

Variable	Wald	HR (95% CI)	P-value
Total vascularization, EFS and OS
Non-informative
Capillaries, EFS and OS
Non-informative
Sinusoids, EFS
Metastatic stage	20.1		0.000
MNA	16.4	3.2 (1.8-5.8)	0.000
Short length	8.6	0.8 (0.7-0.9)	0.003
11qD	8.1	2.2 (1.2-3.9)	0.004
Sinusoids, OS
MNA	24.1	5.0 (2.6-9.5)	0.000
Metastatic stage	19.9		0.000
Short length	9.8	0.8 (0.7-0.9)	0.002
High relative density	6.6	1.0 (1.0-1.1)	0.002
11qD	5.6	2.1 (1.1-4.0)	0.017
Post-capillaries & metarterioles, EFS
Metastatic stage	22.04		0.000
uNB&pdNB	6.9		0.072
Large width	7.7	1.4 (1.1-1.7)	0.005
SCA	4.9	2.5 (1.1-5.7)	0.027
Short length	4.4	0.7 (0.5-0.9)	0.035
Post-capillaries & metarterioles, OS
Non-informative

EFS: Event-free survival, OS: Overall survival, MNA: MYCN amplification, 11qD: 11q deletion, u: undifferentiated NB, pd: poorly differentiated NB, SCA: Segmental chromosome aberrations.