Table 2. Differentially expressed proteins common and unique according to treatment.
| 8 Proteins common to all treatments | 8 Proteins unique to TGFβ-treated stroma | 4 Proteins unique to Exosome-treated stroma | 33 Proteins unique to disease stroma | |||
|---|---|---|---|---|---|---|
| TAGLN | HSPB1 | MAP1A | CALM1 | LGALS1 | RPS16 | AHNAK |
| BASP1 | DES | FLNC | S100A6 | CTTN | SERPINH1 | ENO1 |
| FN1 | TNC | HSPA1A | STMN1 | COX6C | MSN | GSN |
| MYL6 | VDAC1 | H2AFJ | EEF1B2 | LASP1 | ALDOA | LMO7 |
| CALU | VDAC2 | MARCKS | YWHAZ | STOM | AKAP12 | |
| TPM4 | SLC25A3 | CNP | MAP4 | MYH9 | TUBA1A | |
| TGM2 | ATP5B | CFL1 | CD44 | FLNA | VIM | |
| ALDH1A1 | SOD2 | NPM1 | ANXA1 | G6PD | HBA1 | |
| MYH10 | ||||||
Table specifies the identifications according to the Venn diagram (Figure 4D), emphasising proteins which may discriminate the different types of stroma analysed.
TAGLN, Transgelin. BASP1, Brain acid soluble protein 1. FN1, Fibronectin, MYL6, Myosin light polypeptide 6. CALU, Calumenin. TPM4, Tropomyosin alpha-4 chain. ALDH1A1, aldehyde dehydrogenase 1 family member A1. HSPB1, Heat shock protein beta-1. DES, Desmin. TNC, Tenascin-C. VDAC1, Voltage-dependent anion-selective channel protein 1. VDAC2, Voltage-dependent anion-selective channel protein 2. SLC25A3, Phosphate carrier protein, mitochondrial. ATP5B, ATP synthase subunit beta, mitochondrial. SOD2, Superoxide dismutase [Mn], mitochondrial. MAP1A, Microtubule-associated protein 1A. FLNC, Filamin-C. HSPA1A, Heat shock 70 kDa protein 1A/1B. H2AFJ, Histone H2A.J. CALM1, Calmodulin. S100A6, Protein S100-A6. STMN1, Stathmin. EEF1B2, Elongation factor 1-beta. MARCKS, Myristoylated alanine-rich C-kinase substrate. CNP, 2′, 3′-cyclic-nucleotide 3′-phosphodiesterase, CFL1, Cofilin-1. NPM1, Nucleophosmin. MYH10, Myosin-10. LGALS1, Galectin-1. CTTN, Src substrate cortactin. COX6C, Cytochrome c oxidase subunit 6C. LASP1, LIM and SH3 domain protein 1. YWHAZ, 14-3-3 protein zeta/delta. MAP4, Microtubule-associated protein 4. CD44, CD44 antigen. ANXA1, Annexin A1. RPS16, 40S ribosomal protein S16. SERPINH1, Serpin H1. MSN, Moesin. ALDOA, Fructose-bisphosphate aldolase A. STOM, Erythrocyte band 7 integral membrane protein. MYH9, Myosin-9. FLNA, Filamin-A. G6PD, Glucose-6-phosphate 1-dehydrogenase. AHNAK, Neuroblast differentiation-associated protein AHNAK. ENO1, Alpha-enolase. GSN, Gelsolin. LMO7, LIM domain only protein 7. AKAP12, A-kinase anchor protein 12. TUBA1A, Tubulin alpha-1A chain. VIM, Vimentin. HBA1, Hemoglobin subunit alpha.