Table 2. Survival analysis of SKGs using the cox proportional hazard model.
| Cox Univariate | Cox Multivariate with TMZ | Cox Multivariate with Age | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | HR (H vs L) | 95% CI lower | 95% CI upper | Log-Rank p | HR (H vs L) | 95% CI lower | 95% CI upper | Log-Rank p | HR (H vs L) | 95% CI lower | 95% CI upper | Log-Rank p |
| CDCP1 | 1.382 | 1.042 | 1.832 | 0.025 | 1.384 | 1.040 | 1.842 | 0.026 | 1.332 | 1.006 | 1.764 | 0.045 |
| CDK11B | No Data | |||||||||||
| CDKL5 | 1.467 | 1.102 | 1.957 | 0.009 | 1.441 | 1.074 | 1.935 | 0.015 | 1.368 | 1.027 | 1.827 | 0.032 |
| CSNK1E | 0.762 | 0.569 | 1.017 | 0.065 | 0.684 | 0.507 | 0.921 | 0.012 | 0.954 | 0.708 | 1.282 | 0.755 |
| IGF2R | 0.927 | 0.702 | 1.224 | 0.594 | 0.804 | 0.598 | 1.081 | 0.150 | 1.025 | 0.774 | 1.356 | 0.865 |
| IQCD | 1.152 | 0.868 | 1.527 | 0.326 | 1.226 | 0.918 | 1.637 | 0.167 | 1.077 | 0.810 | 1.432 | 0.607 |
| IRAK3 | 1.255 | 0.947 | 1.661 | 0.113 | 1.416 | 1.056 | 1.898 | 0.020 | 1.050 | 0.790 | 1.396 | 0.735 |
| LATS2 | 1.356 | 1.016 | 1.810 | 0.039 | 1.411 | 1.048 | 1.903 | 0.023 | 1.057 | 0.790 | 1.417 | 0.710 |
| MAP4K3 | 1.127 | 0.854 | 1.483 | 0.397 | 1.274 | 0.960 | 1.686 | 0.093 | 1.042 | 0.789 | 1.373 | 0.772 |
| MELK | 1.024 | 0.775 | 1.354 | 0.866 | 1.125 | 0.843 | 1.503 | 0.425 | 0.989 | 0.748 | 1.309 | 0.941 |
| NEK9 | 1.166 | 0.875 | 1.552 | 0.293 | 1.344 | 0.991 | 1.821 | 0.057 | 1.056 | 0.792 | 1.407 | 0.708 |
| PFKP | 0.999 | 0.749 | 1.333 | 0.993 | 0.854 | 0.633 | 1.150 | 0.298 | 1.191 | 0.887 | 1.600 | 0.245 |
| PIK3CB | 1.119 | 0.845 | 1.478 | 0.431 | 1.160 | 0.869 | 1.543 | 0.313 | 0.918 | 0.690 | 1.219 | 0.555 |
| PRKAA1 | 1.372 | 1.034 | 1.822 | 0.029 | 1.499 | 1.120 | 2.006 | 0.006 | 1.227 | 0.923 | 1.633 | 0.159 |
| PRPSAP1 | 1.185 | 0.893 | 1.573 | 0.239 | 1.229 | 0.916 | 1.648 | 0.169 | 1.174 | 0.884 | 1.558 | 0.266 |
| ROR2 | 1.016 | 0.766 | 1.353 | 0.911 | 1.078 | 0.805 | 1.449 | 0.616 | 1.138 | 0.854 | 1.522 | 0.379 |
| STK3 | 1.393 | 1.050 | 1.848 | 0.022 | 1.558 | 1.166 | 2.078 | 0.003 | 1.096 | 0.817 | 1.471 | 0.540 |
| TBRG4 | 1.245 | 0.939 | 1.650 | 0.128 | 1.399 | 1.042 | 1.880 | 0.026 | 1.179 | 0.889 | 1.565 | 0.254 |
| ULK4 | 1.518 | 1.139 | 2.023 | 0.005 | 1.550 | 1.153 | 2.080 | 0.004 | 1.244 | 0.926 | 1.671 | 0.147 |
| VRK1 | 0.950 | 0.717 | 1.260 | 0.722 | 1.050 | 0.785 | 1.407 | 0.743 | 0.976 | 0.737 | 1.295 | 0.864 |
| MGMT | 1.390 | 1.040 | 1.858 | 0.026 | 1.406 | 1.045 | 1.893 | 0.024 | 1.369 | 1.023 | 1.833 | 0.034 |
Data was retrieved from TCGA. HR (H vs L): Hazard ratios comparing the group with high (H) levels of SKGs to the one with low (L) levels. CI: confidence interval. Log-Rank P values less than 0.05 were highlighted in grey.