Figure 1. Sketch of the investigated DNA repair members and folic acid pathway.

The upper line A. depicts the DNA damage response members that were investigated and their mode of action (blue octahedrons). The lower line B. presents a summary of the folic acid metabolism pathway. Yellow spheres represent mRNAs that were assessed via the nCounter technology. Grey spheres were not assessed. A cell membrane is pictured by a pale blue line associated with two spheres, which represent transmembrane proteins. Triangles depict conjugates of folic acid that is substrate/product of the mentioned enzymes. Blue octahedrons represent the final deployment of the modified folic acids.