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. 2016 Feb 26;7(15):20166–20179. doi: 10.18632/oncotarget.7737

Figure 5. Kaplan-Meier curves for mRNA-expression dependant overall survival.

Figure 5

Each line presents the single-fractional and combined Kaplan-Meier curves for A. FOLR1, B. FPGS and C. FPGS/TYMS ratio. The single-fractional curves on the left side display the expression-dependant survival above the chosen threshold (FOLR1=110 mRNA counts, FPGS=590 mRNA counts, and FPGS/TYMS ratio=median=0.4979, empirically determined), whereas the single-fractional curves in the middle depict the survival curve for expression above the mentioned expression. Both curves contain the 95% confidence interval, which is pictured by the dashed lines. The combined survival curve is shown on the right side and contains the p-value, which was obtained by using the COXPH-model and is rounded to the fourth decimal place. The x-axis is a time line and the y-axis displays the number of events in a percentaged scale. Higher expression of FOLR1 and FPGS correlated with prolonged survival and a higher FPGS expression than TYMS expression was identified as further positive prognostic marker.