Table 1. The association of promising SNPs of NER pathway genes with hepatocellular cancer risk.
| Gene | SNP | Genotype | Stage 1 | Stage 2 | Meta | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | Pa | OR (95%CI) | Cases (%) | Controls (%) | Pa | OR(95%CI) | Pa | OR (95%CI) | |||
| n = 169 | n = 501 | n = 401 | n = 401 | |||||||||
| Recognition-related | ||||||||||||
| XPA | rs10817938 | n = 353 | n = 379 | |||||||||
| TT | 105 (62.1) | 311 (62.1) | 1(Ref.) | 208 (58.9) | 241 (63.6) | 1 (Ref.) | ||||||
| TC | 51 (30.2) | 172 (34.3) | 0.525 | 0.88 (0.60–1.30) | 129 (36.5) | 124 (32.7) | 0.263 | 1.19 (0.88–1.63) | 0.537 | 1.08 (0.85–1.36) | ||
| CC | 13 (7.7) | 15 (3.0) | 0.020 | 2.52 (1.16–5.49) | 16 (4.5) | 14 (3.5) | 0.098 | 2.04 (0.88–4.73) | 0.038 | 1.76 (1.03–3.01) | ||
| CC+CT vs. TT | 0.956 | 1.01 (0.70–1.45) | 0.146 | 1.25 (0.93–1.69) | 0.260 | 1.14 (0.91–1.42) | ||||||
| CC vs. TT+TC | 0.012 | 2.66 (1.24–5.74) | 0.136 | 1.88 (0.82–4.33) | 0.045 | 1.72 (1.01–2.91) | ||||||
| XPC | rs1870134 | n = 359 | n = 381 | |||||||||
| GG | 88 (52.1) | 257 (51.3) | 1 (Ref.) | 230 (64.1) | 197 (51.7) | 1 (Ref.) | ||||||
| GC | 76 (45.0) | 204 (40.7) | 0.654 | 1.09 (0.76–1.56) | 114 (31.8) | 160 (42.0) | 0.001 | 0.60 (0.44–0.82) | 0.009 | 0.74 (0.59–0.93) | ||
| CC | 5 (3.0) | 39 (7.8) | 0.048 | 0.39 (0.14–0.99) | 15 (4.2) | 24 (6.3) | 0.067 | 0.53 (0.27–1.05) | 0.002 | 0.44 (0.26–0.75) | ||
| GG vs. CC+GC | 0.869 | 1.03 (1.01–1.47) | 4.7 × 10−4 | 1.67 (1.25–2.27) | 0.001 | 1.45 (1.15–1.79) | ||||||
| GG+GC vs. CC | 0.034 | 2.78 (1.09–7.14) | 0.214 | 1.52 (0.78–2.94) | 0.010 | 1.96 (0.56–3.33) | ||||||
| Unwinding-related | ||||||||||||
| XPD(ERCC2) | rs238417 | n = 345 | n = 372 | |||||||||
| GG | 39 (23.1) | 149 (29.7) | 1 (Ref.) | 127 (36.8) | 148 (39.8) | 1 (Ref.) | ||||||
| GC | 87 (51.5) | 248 (49.5) | 0.191 | 1.33 (0.87–2.05) | 158 (45.8) | 155 (41.7) | 0.249 | 1.21 (0.87–1.68) | 0.491 | 1.09 (0.85–1.40) | ||
| CC | 43 (25.4) | 90 (18.0) | 0.028 | 1.77 (1.06–2.95) | 60 ((17.4) | 69 (18.5) | 0.796 | 1.06 (0.69–1.62) | 0.330 | 1.17 (0.85–1.60) | ||
| CC+GC vs. GG | 0.068 | 1.46 (0.97–2.20) | 0.310 | 1.17 (0.86–1.59) | 0.349 | 1.12 (0.86–1.41) | ||||||
| CC vs. GG+GC | 0.056 | 1.50 (0.99–2.27) | 0.794 | 0.95 (0.65–1.40) | 0.437 | 1.12 (0.85–1.47) | ||||||
| Incision-related | ||||||||||||
| ERCC1 | rs2298881 | n = 329 | n = 388 | |||||||||
| CC | 79 (46.7) | 194 (38.7) | 1 (Ref.) | 104 (31.6) | 145 (37.4) | 1 (Ref.) | ||||||
| CA | 58 (34.3) | 224 (44.7) | 0.027 | 0.64 (0.44–0.95) | 163 (49.5) | 191 (49.2) | 0.302 | 1.19 (0.86–1.65) | 0.953 | 0.99 (0.78–1.27) | ||
| AA | 32 (18.9) | 81 (16.2) | 0.929 | 0.98 (0.60–1.59) | 62 (18.8) | 52 (13.4) | 0.020 | 1.71 (1.09–2.68) | 0.096 | 1.31 (0.95–1.81) | ||
| CA+AA vs. CC | 0.076 | 0.73 (0.51–1.03) | 0.100 | 1.30 (0.95–1.77) | 0.563 | 1.07 (0.85–1.34) | ||||||
| AA vs. CC+CA | 0.427 | 1.20 (0.76–1.89) | 0.036 | 1.54 (1.03–2.31) | 0.061 | 1.32 (0.99–1.77) | ||||||
| rs3212961 | n = 367 | n = 388 | ||||||||||
| CC | 64 (37.9) | 143 (28.5) | 1 (Ref.) | 124 (33.8) | 119 (30.7) | 1 (Ref.) | ||||||
| CA | 66 (39.1) | 251 (50.1) | 0.012 | 0.60 (0.40–0.89) | 158 (43.1) | 188 (48.5) | 0.211 | 0.81 (0.58–1.13) | 0.008 | 0.72 (0.56–0.92) | ||
| AA | 39 (23.1) | 106 (21.2) | 0.422 | 0.83 (0.51–1.32) | 85 (23.2) | 81 (20.9) | 0.889 | 1.03 (0.69–1.53) | 0.600 | 0.92 (0.69–1.24) | ||
| CA+AA vs. CC | 0.028 | 0.66 (0.46–0.96) | 0.392 | 0.88 (0.64–1.19) | 0.032 | 0.78 (0.62–0.98) | ||||||
| AA vs. CC+CA | 0.612 | 1.11 (0.73–1.69) | 0.399 | 1.16 (0.82–1.64) | 0.353 | 1.13 (0.87–1.46) | ||||||
| XPG(ERCC5) | rs873601 | n = 369 | n = 394 | |||||||||
| GG | 54 (32.0) | 142 (28.3) | 1 (Ref.) | 109 (29.5) | 129 (32.7) | 1 (Ref.) | ||||||
| GA | 87 (51.5) | 231 (46.1) | 0.966 | 0.99 (0.66–1.48) | 184 (49.9) | 177 (44.9) | 0.223 | 1.23 (0.88–1.71) | 0.414 | 1.11 (0.87–1.42) | ||
| AA | 28 (16.6) | 126 (25.1) | 0.041 | 0.58 (0.35–0.98) | 76 (20.6) | 88 (22.3) | 0.897 | 1.03 (0.69–1.53) | 0.165 | 0.81 (0.60–1.09) | ||
| AA+GA vs. GG | 0.389 | 0.85 (0.58–1.24) | 0.350 | 1.16 (0.85–1.58) | 0.963 | 1.01 (0.80–1.27) | ||||||
| AA vs. GG+GA | 0.022 | 0.59 (0.37–0.93) | 0.588 | 0.91 (0.64–1.29) | 0.038 | 0.76 (0.58–0.99) | ||||||
a
P value was calculated by adjusted age and sex.