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(A) Structure of ferulic acid. (B) Experimental protocol schedule. On day 7, CCI mice received two oral administrations (10 AM and 6 PM) of ferulic acid (20, 40, 80 mg/kg, p.o.) or vehicle (CMC-Na, p.o.) for 21 days. During treatment, test was done 1 h after the drug administration. After 21 days treatment, antagonists were pre-treated with ferulic acid. Animals were sacrificed immediately after chronic ferulic acid treatment or drug intervention for neurochemical analysis.
