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. 2016 Mar 21;7(15):20999–21012. doi: 10.18632/oncotarget.8236

Figure 4. CXCR4 is a candidate RUNX2-targeting gene.

Figure 4

(A) Among invasion-related candidate RUNX2-targeting genes predicted by bioinformatic analysis, CXCR4 gene was markedly reduced by RUNX2 knockdown in both MGC803 cells (left) and XN0422 cells (right) as detected by qPCR. The expression level of genes was presented as relative fold increased normalized with GAPDH. *P < 0.05, **P < 0.01, Student's t test. (B) Western Blot shows increased CXCR4 in RUNX2-overexpressing SGC7901 cells but decreased CXCR4 in RUNX2-silenced MGC803 and XN0422 cells.