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. 2016 Aug 19;185(3):372–381. doi: 10.1111/cei.12815

Figure 2.

Figure 2

Body weight is temporarily reduced in mice fed 4‐methylumbelliferone (4‐MU). (a,b). Body weight of C57BL/6 (a) and BALB/c (b) mice fed chow containing 5% 4‐MU or control chow. Mice were 9 weeks of age at the initiation of the experiment and were followed‐up to 16–17 weeks of age. (c). Body weight of C57BL/6 mice after induction of experimental autoimmune encephalomyelitis (EAE). Mice were fed chow containing 5% 4‐MU or control chow starting at 8 weeks of age (black arrow), 4 days before immunization (grey arrow). The dotted line depicts the onset of clinical symptoms in this model. (d). Body weight of D011.10xRIPmOVA (DORmO) mice fed chow containing 5% 4‐MU or control chow. Mice were 8 weeks of age at the initiation of the experiment and were followed‐up to 20 weeks of age, at which point 100% of DORmO mice fed control chow were diabetic, while none of the DORmO mice fed 4‐MU were. *P < 0·05, n = 7–12 animals per group.