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. 2016 Jul 25;185(3):271–280. doi: 10.1111/cei.12819

Figure 2.

Figure 2

T cell receptor (TCR) revision generates expanded adaptive immunity but may create autoaggressive TCRs. Th40 cells are induced through CD40 engagement to express recombination‐activating genes (RAG)1 and RAG2. Because viruses have multiple antigens and a broader TCR response would facilitate viral clearance, TCR revision provides an economical means to expand the immune response. A negative consequence would be the potential to generate a non‐negatively selected, autoaggressive T cell.