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. 2016 Jul 26;185(3):361–371. doi: 10.1111/cei.12803

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© 2016 The Authors. Clinical and Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Leukadherin‐1 (LA1) modulates natural killer (NK) cell inflammatory cytokine secretion. Using cytometric bead array we showed that LA1 pretreatment reduced the interferon (IFN)‐γ, tumour necrosis factor (TNF) and macrophage inflammatory protein (MIP)‐1b release in primary NK cell cultures stimulated with (a) interleukin (IL)‐12+IL‐15 (n = 20) and (b) IL‐12+IL‐18 (n = 28). Dimethylsulphoxide (DMSO) provides the carrier control for LA1. Data presented are mean ± standard error of the supernatant cytokine concentration pg/ml at 24 h. Statistical testing by two‐tailed paired t‐test.