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. 2016 Jul 25;185(3):309–319. doi: 10.1111/cei.12825

Figure 1.

Figure 1

Increased CCR7 expression on CD4+ T cells of the DR4+ rheumatoid arthritis (RA) twin (a) and of the DR4+ healthy twin (b) after collagen T cell epitope stimulations compared to unstimulated cells (white peaks versus grey peak, respectively). Increased CCR7 expression (right shift) on the central memory (CM, right cell cloud) and on the effector memory (EM, left cell cloud) CD4+ T cells of the DR4+ RA twin (c) and of the DR4+ healthy twin (d) after collagen epitope stimulations. Stimulating peptides include native (T261‐273) and carbamylated (carT261‐273) T cell epitopes and the combinations with native (B359‐369) or citrullinated (citB359‐369) B cell epitopes, respectively.