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Activated B cells in the DR4+ rheumatoid arthritis twin (a) after the stimulation with the modified collagen epitopes (citB359‐369 and carT261‐273 + citB359‐369) and in the DR4+ healthy twin (panel b) (citB359‐369, T261‐273 + B359‐369 and carT261‐273 + citB359‐369). Stimulating peptides include native (B359‐369) and citrullinated (citB359‐369) B cell epitopes and the combinations with native (T261‐273) and carbamylated (carT261‐273) T cell epitopes, respectively.
