Table 1.
Central memory (CM) and effector memory (EM) CD4+ T cells, CCR7 mean fluorescence intensity (MFI) on CD4+ T cells and activated (CD69+) B cells after collagen epitope stimulations in two human leucocyte antigen DR4‐related (HLA‐DR4)+ monozygotic twins discordant for rheumatoid arthritis (RA) and in an unrelated HLA‐DR3+ case of rheumatoid arthritis (RA)
| DR4+ RA twin | DR4+ healthy twin | DR3+ RA patient | |
|---|---|---|---|
| CM CD4 T cells (%): unstimulated | 82·9 | 87·8 | 74·2 |
| T261–273 | 81·9 | 84·2 | 81·2 |
| carT261–273 | 85·4 | 83·5 | 77·0 |
| T261–273+B359–369 | 85·0 | 81·3 | 63·1 |
| carT261–273+citB359–369 | 83·2 | 83·0 | 81·3 |
| EM CD4 T cells (%): unstimulated | 15·3 | 10·8 | 23·8 |
| T261–273 | 16·5 | 14·6 | 16·5 |
| carT261–273 | 13·4 | 14·4 | 18·3 |
| T261–273+B359–369 | 14·2 | 17·2 | 34·2 |
| carT261–273+citB359–369 | 15·7 | 15·0 | 14·3 |
| CCR7 CD4 T cells (MFI): unstimulated | 1099 | 1822 | 1835 |
| T261–273 | 6370 | 6781 | 1828 |
| carT261–273 | 6845 | 5688 | 1854 |
| T261–273+B359–369 | 6828 | 5796 | 1946 |
| carT261–273+citB359–369 | 6388 | 6582 | 1847 |
| CD69 B cells (%): unstimulated | 17·3 | 16·0 | 47·2 |
| B359–369 | 24·3 | 21·4 | 38·6 |
| citB359–369 | 24·9 | 36·3 | 28·6 |
| T261–273+B359–369 | 22·9 | 46·9 | 28·0 |
| carT261–273+citB359–369 | 29·9 | 46·1 | 34·0 |
| CD69 B cells (MFI): unstimulated | 583 | 570 | 812 |
| B359–369 | 653 | 354 | 786 |
| citB359–369 | 659 | 803 | 606 |
| T261–273+B359–369 | 639 | 809 | 600 |
| carT261–273+citB359–369 | 709 | 801 | 780 |