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. 2016 Aug 1;88(16):8279–8288. doi: 10.1021/acs.analchem.6b02130

Figure 4.

Figure 4

Hyperpolarization of 1-13C-succinate-d2 (SUX) (a) and 1-13C-phospholactate-d2 (PLAC) (b) using parahydrogen induced polarization (PHIP).12,13 1-13C-fumarate-d2 (FUM) and 1-13C-phosphoenolpyruvate-d2 (PEP) molecular precursors undergo catalytic pairwise addition of para-H2 in aqueous medium during continuous-wave (CW) 1H decoupling to yield, respectively, 1H HP products corresponding to the PASADENA regime.14 The 1H polarization of these PASADENA-enhanced protons is then transferred to 13C nucleus using the 3-spin Goldman polarization transfer sequence26 using previously described schemes31,38,55 and known spin–spin couplings.36,55