Table 3.

MIC90 of Drugs Against Mtb from Mtb/Macrophage Aggregates and Nonreplicating Latent Mtb Compared to Active Broth-Grown Mtb

	MIC (μg/mL)
Drugs	Mtb-single	Mtb-aggregate	Mtb-latent	Literaturea
Rifampicin	0.125	>1.0	0.5	0.16
Moxifloxacin	0.3	1.2–2.4	0.3–0.6	0.25
Ciprofloxacin	0.5	4	0.5	0.5
Streptomycin	1.2	4.8	2.4	0.35
Gentamicin	2.0	2.0	ND	6.0
Cycloserine	3.75	7.5	ND	15.6
Clarithromycin	20	10	ND	26

 ^aMIC values against in vitro-grown Mtb reported in the literature.^40,50

 ND, not determined.