Fig. 7.
α7 PAM confirmation concentration–response relationships. (A) Example traces illustrating concentration-dependent effects of sorafenib in PAM mode. Currents were elicited by application of 20 μM (−)-nicotine in presence of sorafenib. (B) Concentration–response curves obtained from integrated current records (5 s, AUC). EC50 values (AUC measurement) were as follows: Sorafenib (4.2 μM), Gefitinib (1.5 μM), Dipyridamole (5.5 μM), and Halcinonide (4.3 μM). Data presented as mean ± SEM (n = 3–4 wells/concentration). AUC, area under the curve.