Table III.
Associations between urinary paracetamol and p-aminophenol concentrations and TTP in partner-specific models (n = 501).
| Partner-specific models |
|||
|---|---|---|---|
| Unadjusted | Adjusteda | Adjustedb | |
| FOR (95% CI) | FOR (95% CI) | FOR (95% CI) | |
| Females | |||
| Paracetamolc | 1.00 (0.96, 1.04) | 1.01 (0.97, 1.06) | 1.01 (0.97, 1.05) |
| Quartile 1: <6.25 ng/ml | — | — | — |
| Quartile 2: 6.25–19.95 ng/ml | 1.22 (0.88, 1.70) | 1.18 (0.84, 1.65) | 1.22 (0.86, 1.72) |
| Quartile 3: 19.95–157 ng/ml | 1.16 (0.82, 1.63) | 1.26 (0.88, 1.80) | 1.38 (0.96, 2.00) |
| Quartile 4: >157 ng/ml | 1.02 (0.71, 1.46) | 1.11 (0.76, 1.61) | 1.34 (0.89, 2.01) |
| P-trend | 0.93 | 0.60 | 0.60 |
| p-aminophenolc | 0.94 (0.86, 1.04) | 0.95 (0.86, 1.05) | 0.98 (0.88, 1.10) |
| Quartile 1: <315 ng/ml | — | — | — |
| Quartile 2: 315–781 ng/ml | 1.19 (0.85, 1.66) | 1.26 (0.87, 1.81) | 1.29 (0.88, 1.89) |
| Quartile 3: 781–1403 ng/ml | 1.33 (0.95, 1.85) | 1.37 (0.96, 1.95) | 1.41 (0.98, 2.03) |
| Quartile 4: >1403 ng/ml | 0.75 (0.53, 1.05) | 0.91 (0.62, 1.35) | 0.93 (0.61, 1.40) |
| P-trend | 0.10 | 0.64 | 0.71 |
| Paracetamol + p-aminophenolc | 1.00 (0.96, 1.04) | 1.01 (0.97, 1.05) | 1.01 (0.97, 1.05) |
| Quartile 1: <410 ng/ml | — | — | — |
| Quartile 2: 410–1020 ng/ml | 0.98 (0.70, 1.37) | 1.02 (0.72, 1.45) | 1.03 (0.73, 1.47) |
| Quartile 3: 1020–2196 ng/ml | 1.11 (0.80, 1.56) | 1.28 (0.90, 1.82) | 1.28 (0.90, 1.82) |
| Quartile 4: >2196 ng/ml | 0.73 (0.51, 1.03) | 0.87 (0.60, 1.27) | 0.88 (0.60, 1.28) |
| P-trend | 0.07 | 0.46 | 0.50 |
| Males | |||
| Paracetamolc | 0.99 (0.96, 1.02) | 0.99 (0.96, 1.02) | 0.99 (0.96, 1.02) |
| Quartile 1: <5.44 ng/ml | — | — | — |
| Quartile 2: 5.44–15.52 ng/ml | 0.88 (0.62, 1.23) | 0.91 (0.64, 1.30) | 0.92 (0.63, 1.33) |
| Quartile 3: 15.52–73.47 ng/ml | 0.97 (0.69, 1.36) | 0.94 (0.65, 1.37) | 0.93 (0.63, 1.37) |
| Quartile 4: >73.47 ng/ml | 0.69 (0.49, 0.97) | 0.67 (0.47, 0.95) | 0.65 (0.45, 0.94) |
| P-trend | 0.03 | 0.02 | 0.02 |
| p-aminophenolc | 0.92 (0.85, 1.00) | 0.92 (0.85, 1.00) | 0.90 (0.81, 1.01) |
| Quartile 1: <500 ng/ml | — | — | — |
| Quartile 2: 500–978 ng/ml | 0.93 (0.66, 1.32) | 0.91 (0.63, 1.31) | 0.93 (0.63, 1.37) |
| Quartile 3: 978–1596 ng/ml | 1.00 (0.70, 1.41) | 1.03 (0.69, 1.54) | 1.04 (0.69, 1.58) |
| Quartile 4: >1596 ng/ml | 0.86 (0.60, 1.23) | 0.82 (0.53, 1.26) | 0.88 (0.55, 1.41) |
| P-trend | 0.41 | 0.36 | 0.43 |
| Paracetamol + p-aminophenolc | 0.99 (0.96, 1.02) | 0.99 (0.96, 1.02) | 0.99 (0.95, 1.02) |
| Quartile 1: <606 ng/ml | — | — | — |
| Quartile 2: 606–1114 ng/ml | 1.12 (0.79, 1.58) | 1.04 (0.72, 1.51) | 1.04 (0.71, 1.51) |
| Quartile 3: 1114–2029 ng/ml | 1.09 (0.76, 1.56) | 1.06 (0.71, 1.59) | 1.08 (0.72, 1.62) |
| Quartile 4: >2029 ng/ml | 0.76 (0.54, 1.07) | 0.69 (0.46, 1.02) | 0.70 (0.47, 1.04) |
| P-trend | 0.12 | 0.06 | 0.02 |
P-trend from Wald test for nonlinearity.
aModels were adjusted for age, BMI, creatinine, smoking status (cotinine dichotomized at a threshold of 10 ng/ml), race/ethnicity (dichotomized, non-White versus White) and income (dichotomized at $70 000).
bModels included covariates in model a and hypertension and hypothyroidism.
cModeled as continuous variable.