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Wtip is required for proper valve development. Sagittal histological section of (A–C) 48 hpf and (D–F) 72 hpf zebrafish embryo hearts. (B,E) wtip morphants (1.035 pmol/embryo) display pericardial edema and (C,F) wtip mRNA (92 pg/embryo) can rescue pericardial edema. Scale bar=10 µm. Wtip, Wilm's tumor 1 interacting protein; hpf, hours post fertilization; conMO, control morpholino oligonucleotide.
