Effect of ZSD on ankle oedema in rats with MSU crystal-induced gouty arthritis. The treatment groups were as follows: Control=normal control rats; Model=MSU crystal-induced rats; Col=MSU crystal-induced rats pretreated with colchicine (0.28 mg/kg); L-ZSD=MSU crystal-induced rats pretreated with ZSD (10 mg/kg); M-ZSD=MSU crystal-induced rats pretreated with ZSD (20 mg/kg); H-ZSD=MSU crystal-induced rats pretreated with ZSD (40 mg/kg). (A) Measurement of the left ankle circumference of each rat was recorded following MSU injection for 24 h. (B) Representative images of the left leg from each group are shown. Arrows indicate the position of the measurement. Data are presented as the mean ± standard deviation (n=6). **P<0.01, vs. control group; ##P<0.01, vs. model group. ZSD, Zisheng Shenqi decoction; MSU, monosodium urate; Col, colchicine.