Figure 5.

(A) Dynamically alternative pathway network. (B) Calcium signaling pathway; the pink rectangle and blue pentagram denoted proteins which were annotated by 'lost' and 'obtained' mRNAs, meaning that they were dynamically regulated lncRNAs in normal and venous congestion condition, respectively. lncRNA, long non-coding RNA; NCX: Na⁺/Ca²⁺ exchanger-3; PMCA, plasma membrane calcium ATPase; GPCR, G protein-coupled receptor; ORAI, calcium release-activated calcium modulator; CAV, certain voltage-activated Ca²⁺ channels; ROC, nicotinic acetylcholine receptor α-7; Gq, guanine nucleotide-binding protein G(q) subunit α; PTK, receptor tyrosine-protein kinase erbB-2; TCR, T cell receptor α-chain V region; BCR, immunoglobulin heavy chain; CD38, ADP-ribosyl cyclase 1; Gs, guanine nucleotide-binding protein G(s) subunit α; ADCY, adenylate cyclase 1; PLC, phosphatidylinositol phospholipase C; SPHK, sphingosine kinase; PKA, protein kinase A; STIM, stromal interaction molecule; PLN, phospholamban; SERCA, Ca²⁺ transporting ATPase, sarcoplasmic/endoplasmic reticulum; RYR, ryanodine receptor; IP3R, inositol 1,4,5-triphosphate receptor type; CALM, calmodulin; VDAC, voltage-dependent anion channel protein; TnC, troponin C, slow skeletal and cardiac muscles; MLCK, myosin-light-chain kinase; PHK, phosphorylase kinase; CaN, serine/threonine-protein phosphatase 2B; CAMK, calcium/calmodulin-dependent protein kinase; NOS, nitric-oxide synthase; PDE1, phosphodiesterase 1; FAK2, focal adhesion kinase 2; IP33K, 1D-myo-inositol-triphosphate 3-kinase; PKC, protein kinase C.