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. Author manuscript; available in PMC: 2016 Aug 19.
Published in final edited form as: Immunity. 2012 Sep 13;37(3):574–587. doi: 10.1016/j.immuni.2012.06.016

Figure 4. iNKT null mice have more pro-inflammatory cytokines and macrophages on a SFD.

Figure 4

(a) Weight of wt, Jα18−/−, and CD1d1−/− mice fed SFD ad lib until 20 weeks of age (n=3 per group, one-way ANOVA with post-hoc Tukey). (b) Adipocyte size in wt, Jα18-deficient and CD1d1−/− mice on SFD (representative of 3 mice per group). (c) Macrophage level and phenotype in the 3 mice groups on SFD. Left top, total macrophages, and bottom, M2 (CD206+) macrophages, CD206 hi (top gate), CD206lo (middle gate) and CD206− (bottom gate). (d) Fasting serum triglyceride (TGL) concentration in the 3 groups (n=3, all one-way ANOVA with post-hoc Tukey). Serum TNFα and IL-6 concentration in wt and Jα18−/− mice on SFD (n=3, t test), CD1d1−/− mice not tested. (e) Fasting glucose and glucose tolerance of 20 week old wt, Jα18−/−, and CD1d1−/− mice on SFD. Graphs show mean+ s.d. *p<0.05, **, p<0.01, ***p<0.0001.