. Author manuscript; available in PMC: 2016 Aug 19.

Published in final edited form as: Clin Genet. 2013 Feb 21;84(6):546–551. doi: 10.1111/cge.12109

Table 2.

Premutation Molecular Characteristics (A) and Association with Migraine Risk (B).

(A)	Premutations with history of Migraine		Premutations without history of Migraine
(A)	Mean (N)	SD	Mean (N)	SD	P-value
CGG size	87 (130)	18	90 (168)	19	0.216
FMR1 mRNA	2.32 (124)	0.63	2.53 (152)	0.77	0.013
Activation Ratio	0.51 (97)	0.19	0.53 (81)	0.19	0.625
(B)	Association with Migraine Risk
(B)	Relative Risk	95% Confidence interval	P-value^*
CGG size	0.993	0.984 – 1.001	0.096
FMR1 mRNA	0.939	0.746-1.183	0.594

Multivariate model adjusting for age and sex based on available data on 275 FMR1 premutation carriers (123/152 with/without migraine).