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. 2016 Jun 2;23(4):395–402. doi: 10.1093/dnares/dsw018

Table 3.

Relationships between oxidative damage at the TP53 level and the mutational spectrum of the TP53 in malignant breast tumours

Codon number Site of DNA lesione RI ± s.e.a Ratiob Nomenclature Tumour distribution (%) Mutational event Mutational rateb (%)
163 (-TAC-) 0.19 ± 0.02 1.27 c.487T>A 0.28 A:T→T:A 6.57
170 (-ACG-) 0.51 ± 0.04 1.7 c.511G>A 0.03 G:C→A:T 20.68
173 (-GTG-) 0.44 ± 0.05 1.57 c.517G>T 0.31 G:C→T:A 10.58
175 (-CGC-) 0.23 ± 0.03 1.27 at CpG c.524G>A 4.52 G:C→A:T at CpG 18.37

aThe mean levels of oxidative lesions, expressed as relative intensity (RI), in breast cancer patients.

bRatio = levels of oxidative damage at the TP53 sequence levels in breast cancer cases/levels of oxidative DNA damage of controls.

cPrevalence of mutations at the site of DNA lesions at the TP53 sequence level.

dPrevalence of transversion and transition mutations in the TP53.

eUnderlined letters indicate the residues for which oxidative lesions are reported.