Fig. 4.

Network 2 (DNA Replication, Recombination, and Repair, Energy Production, Nucleic Acid Metabolism) identified from maternal smoking effects on the proteome of the term human placenta. Networks were generated through the use of Ingenuity Pathway analysis. The intensity of color represents degree of up-regulation (purple) and down-regulation (red). A key to the identity of the node shapes is included in the figure. Dashed and solid lines represent indirect and direct interactions respectively. Lines without arrows indicate binding while closed arrows indicate action of first on second node and open arrows indicate translocation from first to second node. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)