Table 2.
Comparison of the biochemical data between the non-smoking and smoking groups.
| Variable | Non-smokers (n = 7) | Smokers (n = 7) | p-valuea |
|---|---|---|---|
| Blood cotinine (ng/ml) | <2.00b | 51.51 ± 26.94 (16.78–96.84) |
– |
| EROD (pmol*mg/min) | 0.30 ± 0.34 (0.02–0.78) |
151.28 ± 180.56 (1.77–516.28) |
0.001** |
| ECOD (pmol*mg/min) | 5.50 ± 4.14 (1.93–13.86) |
297.38 ± 264.79 (13.02–782.60) |
0.001** |
| AROM (pmol*mg/min) | 33.01 ± 7.28 (22.05–45.28) |
27.78 ± 31.36 (10.84–98.26) |
0.026* |
| GST (nmol*mg/min) | 178.89 ± 36.45 (126.19–219.25) |
230.41 ± 85.89 (183.98–418.27) |
0.209 |
| UGT (pmol*mg/min) | 5.00 ± 1.38 (3.66–7.28) |
5.37 ± 1.89 (3.65–8.69) |
0.902 |
Values are shown as mean ± SD and range in brackets below.
EROD = 7-ethoxyresorufin O-deethylase, ECOD = 7-ethoxycoumarin O-deethylase, AROM = aromatase, GST = glutathione S-transferase, UGT = uridine 5′-diphospho-glucuronosyltransferase.
a
As determined by Mann-Whitney U test.
b
Below limit of quantitation. Non-smokers vs. smokers.
*
p < 0.05.
**
p < 0.01.