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. Author manuscript; available in PMC: 2016 Aug 19.
Published in final edited form as: Nature. 2014 Feb 14;506(7488):328–333. doi: 10.1038/nature13038

Figure 1. Recurrent somatic DNMT3a mutations are common in T-cells from AML patients.

Figure 1

a, Summary of the allele frequency (%) of missense and frameshift somatic single nucleotide variants (sSNV) in AML-related genes assessed by deep targeted sequencing (read depth 250×) in AML blasts and T cells from the peripheral blood of 12 AML patients. The sSNV numbers indicated at the top of the table correspond to the numbers in Supplementary Table 3. Somatic mutations in DNMT3a (*, R882H; †, R137C) were found in both T-cells and AML blasts in Patients #9, 11 and 12. Patient #12 also had a low frequency IDH2 mutation (‡, R140L) in T cells. b, Frequency (%) of DNMT3amut and NPM1c in freshly isolated CD33+ blasts (AML) and matched T-cell controls from 17 patients with normal karyotype AML, as determined by droplet digital PCR. For a and b, the length of the bars is proportional to the mutant allele frequency (the scale bar under the first column applies to all columns).